Welcome to FIS   Sponsored By
United States
Subscribe to FIS | Register with FIS | Advertise with FIS | Newsletter | About FIS | Contact us
   


Anchovy is one of the omega-3 oil richest fish. (Photo: NOAA / FIS)(Photo Credit: NOAA/FIS)

Omega-3 fatty acids may provide more benefits than thought

Click on the flag for more information about United States UNITED STATES
Monday, January 27, 2014, 22:50 (GMT + 9)

A study of the metabolic effects of omega-3 fatty acids, especially DHA, concludes that these compounds may have an even wider range of biological impacts than previously considered, and suggests they could be of significant value in the prevention of fatty liver disease.

The research, done by scientists at Oregon State University and several other institutions, was one of the first of its type to use “metabolomics,” an analysis of metabolites that reflect the many biological effects of omega-3 fatty acids on the liver. It also explored the challenges this organ faces from the “Western diet” that increasingly is linked to liver inflammation, fibrosis, cirrhosis and sometimes liver failure.

The findings, which researchers say were surprising, were published last month in PLOS One.

Supplements of DHA, used at levels that are sometimes prescribed to reduce blood triglycerides, appeared to have many unanticipated effects. There were observable changes in vitamin and carbohydrate metabolism, protein and amino acid function, as well as lipid metabolism.

Supplementation with DHA partially or totally prevented metabolic damage through those pathways often linked to the Western diet – excessive consumption of red meat, sugar, saturated fat and processed grains.

“We were shocked to find so many biological pathways being affected by omega-3 fatty acids,” said Donald Jump, a professor in the OSU College of Public Health and Human Sciences. “Most studies on these nutrients find effects on lipid metabolism and inflammation.

“Our metabolomics analysis indicates that the effects of omega-3 fatty acids extend beyond that, and include carbohydrate, amino acid and vitamin metabolism,” he added.

Omega-3 fatty acids have been the subject of much recent research, often with conflicting results and claims. Possible reasons for contradictory findings, OSU researchers say, are the amount of supplements used and the relative abundance of two common omega-3s – DHA and EPA. Studies at OSU have concluded that DHA has far more ability than EPA to prevent the formation of harmful metabolites. In one study, it was found that DHA supplementation reduced the proteins involved in liver fibrosis by more than 65 percent.

These research efforts, done with laboratory animals, used a level of DHA supplementation that would equate to about 2-4 grams per day for an average person. In the diet, the most common source of DHA is fatty fish, such as salmon, mackerel or sardines.

The most recent research is beginning to break down the specific processes by which these metabolic changes take place. If anything, the results suggest that DHA may have even more health value than previously thought.

“A lot of work has been done on fatty liver disease, and we are just beginning to explore the potential for DHA in preventing or slowing disease progression,” said Jump, who is also a principal investigator in OSU’s Linus Pauling Institute.

“Fish oils, a common supplement used to provide omega-3, are also not prescribed to regulate blood glucose levels in diabetic patients,” he said. “But our studies suggest that DHA may reduce the formation of harmful glucose metabolites linked to diabetic complications.”

Both diabetes and liver disease are increasing steadily in the United States.

The American Liver Foundation has estimated that about 25 per cent of the nation’s population, and 75 percent of those who are obese, have nonalcoholic fatty liver disease. This can progress to nonalcoholic steatohepatitis, cirrhosis and cancer.

This study established that the main target of DHA in the liver is the control of inflammation, oxidative stress and fibrosis, which are the characteristics of more progressively serious liver problems. Omega-3 fatty acids appear to keep cells from responding to and being damaged by whatever is causing inflammation.
 

Source: Oregon Statate University

editorial@fis.com
www.fis.com


 Print


Click to know how to advertise in FIS
MORE NEWS
Spain
Oct 24, 23:50 (GMT + 9):
Spain calls for increased bluefin tuna TAC for EU fleet
Chile
Oct 24, 23:20 (GMT + 9):
Ager acquires PescaChile assets, sets trade agreement with Europacífico
Chile
Oct 24, 23:10 (GMT + 9):
Global Salmon Initiative launches first progress report
India
Oct 24, 22:40 (GMT + 9):
IN BRIEF - India's first fish hospital to come up in Kolkata
South Africa
Oct 24, 22:40 (GMT + 9):
IN BRIEF - Pirates threaten fishing industry
United States
Oct 24, 22:40 (GMT + 9):
IN BRIEF - City faces 'direct hit' in fish losses
Argentina
Oct 24, 22:40 (GMT + 9):
Anchovy and cartilaginous fish management measures defined in Argentine-Uruguay zone
Iceland
Oct 24, 22:30 (GMT + 9):
IN BRIEF - Negotiations on the sale of shares in Stofnfiskur hf.
Australia
Oct 24, 22:30 (GMT + 9):
IN BRIEF - Spencer Gulf prawn fleet helps a new management plan to protect the industry into the future
Canada
Oct 24, 22:20 (GMT + 9):
Top marine scientists call for action on 'invisible' fisheries
Norway
Oct 24, 22:00 (GMT + 9):
IN BRIEF - HAVFISK :Financial calendar for 2015
Norway
Oct 24, 21:50 (GMT + 9):
Salmon price status at week 43
American Samoa
Oct 24, 04:00 (GMT + 9):
Kiribati's decision worries local and American tuna entrepreneurs
Spain
Oct 24, 03:10 (GMT + 9):
France has doubts about Galician mussel
Chile
Oct 24, 02:30 (GMT + 9):
Marine Harvest records increased harvest and operating income



Lenguaje
FEATURED EVENTS
  
TOP STORIES
Shipowners require 'level playing field' for all fleets fishing for sharks
Spain Two organizations of the fishing longlining sector ascribed to the Cooperative of Shipowners of the Port of Vigo demand that Spain and other Member States must require the EC to promote non-shark finning regulations.
Salmon importer joins Japanese giant firm SNG subsidiary
United States The salmon importing and distributing firm SalmonDepot USA has confirmed its merger with SNG UK, Ltd., the European operating branch of Shin Nihon Global.
Kiribati's decision worries local and American tuna entrepreneurs
American Samoa Kiribati's decision to reduce the fishing days in its waters could be devastating for the local community, according to Tuna industry leaders in American Samoa.
Industrial anchovy fishing season opening faces risks
Peru A recent report issued by experts of the Peruvian Marine Institute suggests that this year a second industrial anchovy fishing season may not be allowed around the Peruvian coast.
 
Maruha Nichiro Corporation
Nichirei Corporation -Headquarter-
Pesquera El Golfo S.A.
Ventisqueros - Productos del Mar Ventisqueros S.A
Wärtsilä Corporation -Wartsila Group Headquarter-
ITOCHU Corporation -Headquarter-
BAADER - Nordischer Maschinenbau Rud. Baader GmbH (Head Office)
Inmarsat plc - Global Headquarters
Marks & Spencer
Tesco PLC (Supermarket) - Headquarters
Pescanova, S.A. - Group Headquarters
Sea Harvest Corporation (PTY) Ltd.
I&J - Irvin & Johnson Limited
Blue Continent Products (Pty) Ltd - (Oceana Group Limited)
Pesquera San Jose S.A.
Nutreco N.V. - Head Office
CNFC China National Fisheries Corporation - Group Headquarters
W. van der Zwan & Zn. B.V.
SMMI - Sunderland Marine Mutual Insurance Co., Ltd. - Headquarters
Icicle Seafoods Inc. -Headquarter-
Starkist Seafood Co. - Headquearters
Trident Seafoods Corp.
American Seafoods Group LLC - Head Office
Marel ehf - Group Headquarters
SalMar ASA - Group Headquarters
Sajo Industries Co., Ltd
Hansung Enterprise Co.,Ltd.
BIM - Irish Sea Fisheries Board (An Bord Iascaigh Mhara)
CEFAS - Centre for Environment, Fisheries & Aquaculture Science
COPEINCA ASA - Corporacion Pesquera Inca S.A.C.
Chun Cheng Fishery Enterprise Pte Ltd.
Food Project (Siam) Co., Ltd.
VASEP - Vietnam Association of Seafood Exporters & Producers
Gomes da Costa
Furuno Electric Co., Ltd. (Headquarters)
NISSUI - Nippon Suisan Kaisha, Ltd. - Group Headquarters
FAO -Food and Agriculture Organization- Fisheries and Aquaculture Department (Headquarter)
Hagoromo Foods Co., Ltd.
Koden Electronics Co., Ltd. (Headquarters)
A.P. Møller - Maersk A/S - Headquarters
BVQI - Bureau Veritas Quality International (Head Office)
UPS - United Parcel Service, Inc. - Headquarters
Hamburg Süd Group - (Headquearters)
Armadora Pereira S.A. - Group Headquarters
NOAA - National Oceanic and Atmospheric Administration (Headquarters)
Omega Protein Corporation -Headquarter-
Grupo Calvo - Luis Calvo Sanz, S.A. (Group Headquarter)
Marona S.A.
Marine Harvest ASA - Headquarters
Marubeni Europe Plc -UK-
Findus Ltd
Icom Inc. (Headquarter)
WWF Centroamerica
Oceana Group Limited
The David and Lucile Packard Foundation
Ajinomoto Co., Inc. -Headquarter-
Friosur S.A. - Headquarters
Cargill, Incorporated - Global Headquarters
Benihana Inc.
Leardini Pescados Ltda
Mitsubishi Corporation Marine Products Depts. D.Team
CJ Corporation  -Holding Headquarter-
Greenpeace International - The Netherlands
David Suzuki Foundation
Fisheries and Oceans Canada -Communications Branch-
Mitsui & Co.,Ltd - Headquarters
Ocean Trawlers Group - Ocean Trawlers HK Ltd.
Natori Co., Ltd.
Carrefour Supermarket - Headquarters
FedEx Corporation -Headquarter-
AKBM - Aker BioMarine ASA
Seafood Choices Alliance -Headquarter-
Austevoll Seafood ASA
Walmart / Wal-Mart Stores, Inc. (Supermarket) -Headquarter-
New Japan Radio Co.Ltd (JRC) -Head Office-
Gulfstream JSC
INVE Group - Head Office
Marine Stewardship Council - MSC Worldwide Headquarters
Royal Dutch Shell plc (Headquarter)
Genki Sushi Co.,Ltd -Headquarter-
Iceland Pelagic ehf
AXA Assistance Argentina S.A.
Caterpillar Inc. - Headquarters
Tiger Brands Limited
Morpol ASA - Group Headquarters
SeaChoice
National Geographic Society
AmazonFresh, LLC - AmazonFresh

Copyright 1995 - 2014 Fish Info & Services Co.Ltd| All Rights Reserved.   DISCLAIMER